[Biological characteristics of translocating bacteria during experimental otitis media] Zhurnal mikrobiologii, epidemiologii, i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] Journal article | | Title | [Biological characteristics of translocating bacteria during experimental otitis media] | | Source | Zh Mikrobiol Epidemiol Immunobiol 2009 Jul-Aug; (4):12-5. | | Abstract | AIM: To study dynamics of species composition, factors of pathogenicity and persistence, index of microbial load by bacteria translocating to tympanic cavity from nasal cavity.
MATERIALS AND METHODS: Translocation of bacteria was reproduced on the model of experimental staphylococcal purulent otitis media in 22 adult rabbits from "chinchilla" breed. Identification of translocating strains was performed by radioisotope label. Microflora of nasopharynx and middle ear was studied on day 4, 6, 10, 20, 30, and 180 after inoculation.
RESULTS: Translocating strains differed from nontranslocating by higher level of antilysozyme activity (> or =3 mcg/ml) and higher proportion of their microbial load in total index of microbial load of source biotope (> or =5%). During unfavorable course of otitis, increase of pathogenicity of strains-translocants in circumstances of microbial interaction was observed.
CONCLUSION: One of the mechanisms for the development of otitis media is translocation of indigenous bacteria and their associates to the inflammation site in middle ear where microbial interactions determine the outcome of infection. Results of experimental studies allowed to develop the method for prediction of otitis media course. | | Language | rus | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19718825 |
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